Mr Vice President,

The United Kingdom thanks the Independent Expert for his report.

We remain deeply concerned by the situation in Mali, and by the tragic impact that it has on the lives of many in the country. Since the suspension of this session, COVID-19 has added an extra layer of complexity.

We welcome steps taken to implement the peace agreement, but call on the Government to sustain momentum; this includes the enactment of the Inclusive National Dialogue’s key recommendations. The Malian people urgently need their Government to provide basic services and good governance in all regions.

We support the Malian Authorities in the difficult tasks of restoring stability. The Government must respect its human rights obligations and take measures to prevent and punish violations and abuses committed by both state and non-state actors, including by delivering thorough, fair and impartial investigations into allegations.

Gender equality is fundamental to building peaceful, stable societies. The report’s findings on the situation of women and girls is particularly concerning and we support calls to make the political system more inclusive.

Mr Tine,

How can the Malian Government best follow up on the report which will be published in June 2020 on historic crimes committed in Mali between 2012 and 2018?

Thank you

Thank you Mr. Vice President,

The United Kingdom welcomes the oral update provided by the High Commissioner and the International Expert team.

We welcome the High Commissioner’s visit to DRC in January and the focus on inter-ethnic human rights violations within Ituri. We urge DRC’s Government to continue its efforts to end violence, tackle impunity and address corruption.

While we are encouraged by the Government’s commitment to work with the international community, the UK remains concerned by DRC’s human rights situation. In particular, reports of increased abuses by armed groups in conflict-affected areas, noting the recent escalation of violence in Ituri. We are also concerned that COVID-19 risks undermining progress made by the DRC government on addressing human rights. The Joint Office for Human Rights has reported incidents of state agents violating human rights while implementing measures to address the pandemic. In addition, the poor conditions in prisons across DRC are leaving detainees in desperate need, and risk prisons becoming hubs for transmission.

Madam, High Commissioner,

We would welcome an update on how the Government is strengthening local human rights mechanisms, their capacity to investigate violence such as the events in Yumbi in December 2018, and the implementation of the Universal Periodic Review recommendations made in May 2019.

Thank you.

• Government offers contracts to develop new antibiotics to treat deadliest diseases
• NHS patients could benefit from new antibiotic treatments as early as 2022
• New drugs will be paid for by world’s first ‘subscription-style’ payment model for antibiotics

The NHS is offering 2 contracts to pay pharmaceutical companies at the start of their work for access to innovative antibiotics, incentivising them to bring new classes of the drugs to patients across the UK for the first time in almost 30 years.

Of particular interest are antibiotics that can provide alternative treatment options for serious infections, such as bloodstream infections, sepsis and hospital-acquired pneumonia.

The high cost and low returns associated with antibiotic research and development makes it commercially unattractive. This is why the drugs will be paid for by the world’s first ‘subscription-style’ payment model for antibiotics and will be made available to UK patients as soon as possible, potentially as early as 2022.

Health Secretary Matt Hancock said:

The incredible discovery of antibiotics nearly 100 years ago transformed the health of our nation and our ability to combat infections. Diseases that were once a death sentence are now treated in just one small step.

But resistance to antibiotics is increasing and it’s imperative we take urgent action on a national and global scale to protect future generations.

This new way of buying antibiotics for patients in the NHS breaks down restrictive barriers to offer companies a vital springboard to foster innovation and develop potentially life-saving new products.

Professor Dame Sally Davies, UK Special Envoy on Antimicrobial Resistance, said: 

Antibiotics underpin modern medicine and are integral for global health security. Governments and industry must work together to produce new antibiotics and ensure that we can continue to treat common diseases.

The UK is leading the way by encouraging companies to produce new antibiotics to stay one step ahead of life-threatening diseases.

The payment model, which was launched in July 2019, will pay pharmaceutical companies upfront for access to their antibiotic product, based on a product’s value to the NHS, rather than how much is used.

This aims to incentivise companies to invest in researching and developing new antibiotics, helping secure much-needed alternative treatment options for NHS patients.

Two drugs that have proven to be both safe and effective will be selected to undergo health technology assessment (HTA) by the National Institute for Health and Care Excellence (NICE) throughout 2021 using adapted methods for antimicrobials. The HTA will be used to decide the level of the subscription payment.

From this week, suppliers can register their interest for the scheme on NHS England’s eTendering Service.

The UK is at the very forefront of the global fight against antimicrobial resistance (AMR), launching its 5-year national action plan in 2019 and setting out its vision for AMR to be contained and controlled by 2040.

Yet, tackling AMR will require a global effort and the government is today calling for other countries to offer similar incentives in their own domestic markets.

Professor Stephen Powis, National Medical Director, NHS England said:

Staff across the NHS are already working with patients to ensure the antibiotics we have are used in the right way at the right time, and this new scheme is further important progress to develop new, life-saving antimicrobial medicines.

People’s lives depend on us having effective antibiotics and steps like this further reinforce how the NHS is leading the way in efforts to safeguard against the rise of superbugs.

Professor Gill Leng, Chief Executive, NICE, said:

We are witnessing the effects of one global pandemic, which has highlighted the threat of communicable disease.  Alongside the threat of coronavirus is the increasing risk posed by antimicrobial resistance, exacerbated by a sparse antimicrobial development pipeline.

That is why we need to incentivise investment in innovative antimicrobial drug development as soon as possible. Along with our key partners, we have committed to develop and test innovative models for the evaluation and purchase of antimicrobials, applying advanced evaluation methods that recognise their full value to public health.

We hope that this project will inspire healthcare systems across the world to consider adopting similar models so that collectively, we deliver meaningful incentives that reinvigorate the global antimicrobial pipeline.

• The need to address the urgent issue of bringing new antimicrobials to market is widely recognised. Few new classes of antibiotic have been discovered since the 1980s and, for most antimicrobials, there are few replacement or alternative products in development and even fewer that target priority pathogens.
• The high cost and low returns associated with research and development of novel antimicrobials makes it commercially unattractive. In addition, pharmaceutical company revenues depend on volume of sales, potentially undermining antimicrobial stewardship initiatives.
• The UK is the first country in the world to announce it will test innovative models that pay companies for antimicrobials based primarily on a health technology assessment of their overall value to the NHS, as opposed to the volumes used.
• The subscription-style payment model will mean the NHS will have new drugs to call on when needed, while companies will be able to reliably forecast the return on their investment.
• A notice will be published on the Official Journal of the European Union website in the next 2 to 5 days.
• Once the notice is live, suppliers can register their interest via https://nhsengland.bravosolution.co.uk. Instructions and selection criteria will be published as part of this notice. Once released the procurement documents can also be found on the NICE website.
• Two procurement exercises will be run in parallel: one for an antimicrobial recently introduced to the UK market, and a second for a new antimicrobial with plans to launch in the UK before January 2021.
• The selection process has been designed to favour products which meet a key need in the UK while also addressing disease areas of international importance. Points will also be awarded for degree of novelty, surety of supply, the supplier’s demonstrated commitment to antimicrobial and environmental stewardship, and commitment to support surveillance.
• Products will be selected by the end of this year, and these selected products will progress to the HTA stage in 2021 to estimate the value of each product to the NHS. Contracts for the 2 antibiotic products are due to start in April 2022.
• The scope of the current procurement is the NHS in England. The expectation is that, if the project is successful, future rollout of these purchasing arrangements could be UK-wide.